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KMID : 0380020090240020201
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 2 p.201 ~ p.206
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Antiproliferative Effect of Extracts from Corydalis heterocarpa on Human Cancer Cells
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Kim You-Ah
Lee Jung-Im
Kong Chang-Suk
Yea Sung-Su
Seo Young-Wan
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Abstract
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Whole plants of Corydalis heterocarpa were extracted twice with and MeOH in turn. The combined crude extracts were concentrated in vacuo and then partitioned between and . The organic layer was fractionated with n-hexane and 85% aq. MeOH, and the aqueous fraction was also further fractionated with n-BuOH and , successively. Growth inhibition effects of crude extracts and their solvent fractions were evaluated in AGS, HT1080, U-937, MCF-7 and HT-29 human cancer cells using MTT assay. The inhibitory effects of solvent fractions were increased in a dose-dependent manner. Among these tested samples, 85% aq. MeOH fraction showed the most potent inhibitory effect on the growth of human cancer cells. These results suggest that active compounds having much stronger anticancer effect can be isolated from Corydalis heterocarpa.
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KEYWORD
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Corydalis heterocarpa, anticancer, human cancer cells
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